Grimm's hydride displacement law
Grimm's Hydride Displacement Law is an early hypothesis to describe bioisosterism, the ability of certain chemical groups to function as or mimic other chemical groups.[1][2]
- “Atoms anywhere up to four places in the periodic system before an inert gas change their properties by uniting with one to four hydrogen atoms, in such a manner that the resulting combinations behave like pseudoatoms, which are similar to elements in the groups one to four places respectively, to their right.”[3]
According to Grimm, each vertical column (of Table 1) would represent a group of isosteres.
Table 1: Grimm's Hydride Displacement Law
C |
N |
O |
F |
Ne |
Na |
|
CH |
NH |
OH |
FH |
- |
|
|
CH2 |
NH2 |
OH2 |
FH2+ |
|
|
|
CH3 |
NH3 |
OH3+ |
|
|
|
|
CH4 |
NH4+ |
References
- ^ Grimm, H. G. Structure and Size of the Non-metallic Hydrides Z. Electrochem. 1925, 31, 474-480.
- ^ Grimm, H. G. On the Systematic Arrangement of Chemical Compounds from the Perspective of Research on Atomic Composition; and on Some Challenges in Experimental Chemistry. Naturwissenschaften 1929, 17, 557-564.
- ^ Patani, G. A.; LaVoie, E. J. Bioisosterism: A Rational Approach in Drug Design. Chem. Rev. 1996, 96, 3147-3176. (doi:10.1021/cr950066q)